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KMID : 0931320240240010064
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대한상부위장관.헬리코박터학회지
2024 Volume.24 No. 1 p.64 ~ p.71
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Long Term Clinical Outcomes of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma: A Single Center Study
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Koh Seong-Hyun
Yeo Seung-Hyun
Park Moo-In
Jung Kyoung-Won
Kim Sung-Eun
Moon Won
Park Seun-Ja
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Abstract
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Objectives: Few studies have reported long-term follow-up after treatment of gastric mucosaassociated lymphoid tissue (MALT) lymphoma.
In this single-center study, we investigated longterm treatment outcomes in patients diagnosed with gastric MALT lymphoma.
Methods: The study included 80 patients diagnosed with gastric MALT lymphoma, who were followed up at a single center between January 2005 and December 2019 after Helicobacter pylori eradication therapy, radiotherapy, or chemotherapy.
We evaluated complete remission, improvement, or recurrence of the lesion.
Follow-up over >60 months was classified as long-term follow-up, and the progression-free survival rate was recorded.
Results: Following H. pylori eradication treatment, complete remission occurred in 85.9% (55/64) of H. pylori-positive and 50.0% (3/6) of H. pylorinegative patients.
All patients with gastric MALT lymphoma who did not respond to H. pylori eradication therapy (100.0% [6/6]) achieved complete remission following administration of local radiotherapy. We observed no deaths on long-term follow-up (>60 months), and the progression-free survival was 101 months.
Conclusions: In this study, patients with gastric MALT lymphoma showed excellent survival rates, progression-free survival, and prognosis on long-term follow-up. Prospective studies are warranted to determine the long-term prognosis of gastric MALT lymphoma after treatment.
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KEYWORD
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Lymphoma, Stomach neoplasm, Helicobacter pylori, Progression-free survival
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